The Role of Long Noncoding RNA AL161431.1 in the Development and Progression of Pancreatic Cancer

Pancreatic cancer is known for its notorious fast progression and poor prognosis. Long noncoding RNA (lncRNA) AL161431.1 has been reported to be involved in the pathogenesis of different cancers. In this study, we explored role lncRNA development pancreatic by bioinformatic analysis, vitro vivo experiments BxPC-3 SW1990 cells, as well clinical samples. We found that was highly expressed cells tissues. Knock down led increased cell death cycle arrest. Xenograft growth with stable knockdown mice significantly slower than scrambled control shRNA. Finally, showed involvement related promotion epithelial mesenchymal transition process.